EVENT KOD-KSI101-2026
SCORED SET ITT
FLOOR floor_bcva_signal Floor: disclose a BCVA gain of at least 10 letters, using the prior APEX early-response magnitude. ["Rapid vision improvements and anatomical response were observed with 10-letter gains by Week 4 in top dose groups and OCT CST <325 microns achieved as early as Week 1 in top dose groups." - ## prior_topline_pr_8]
BAR bar_bcva_gain Bar: disclose at least 15 letters of BCVA gain, matching the prior APEX visual-response magnitude. ["More than half of patients achieved ≥15-letter gains in best corrected visual acuity, with additional benefit at higher dose levels." - ## prior_topline_pr_8]
DIFF diff_retinal_dryness Differentiator: at least 90% complete absence of IRF and SRF, indicating retinal dryness. ["In top dose groups, ≥90% achieved complete absence of IRF and SRF, indicating retinal dryness and normalization of retinal architecture." - ## prior_topline_pr_8]
DIFF diff_oct_cst Differentiator: OCT CST below 325 microns as an anatomical response signal. ["Rapid vision improvements and anatomical response were observed with 10-letter gains by Week 4 in top dose groups and OCT CST <325 microns achieved as early as Week 1 in top dose groups." - ## prior_topline_pr_8]